A Success Story

Glucosamine Sulphate proves worth in long term osteoarthritis trial. The latest research findings on glucosamine sulphate were recently detailed in a landmark study published in The Lancet, the well known British medical journal.

Researchers found no significant joint-space loss after three years in the 106 patients treated with glucosamine sulphate. However, among the 106 patients on a placebo there was a progressive joint space narrowing, with a mean joint-space loss of 0.31mm. Those who were treated had a 20 to 25 per cent improvement in symptoms, compared with a slight worsening of symptoms in the placebo group. Dr Tim McAlindon, of the Arthritis Centre, Boston University Medical Centre, says "the results are impressive; patients assigned to glucosamine experienced significant improvements in pain and disability that were sustained for the 3 years of the study, whereas the scores among the placebo group worsened. Further more, adverse event rates were not higher than those associated with placebo. These findings are consistent with those seen in previous symptom based studies of glucosamine. Even though the effect sizes are modest, glucosamine sulphate could play an important part in the longterm therapy of Osteoarthritis."

Research by Georges M. Halpern MD, PhD (Author of Inflammatory Revolution)

As questions mount about the safety of man-made anti-inflammatories, both doctors and arthritis sufferers are turning their attention to natural alternatives such as the oil of the New Zealand green-lipped mussel (Perna canaliculus). A significant body of scientific evidence exists to show that the oil of the New Zealand green-lipped mussel is safe, free of any known side effects and among the most potent anti-inflammatories known to medicine. When these facts are contrasted with the withdrawal of the anti-inflammatory drug Vioxx, after it was linked to heart attacks, and serious questions about the safety of other drugs, a natural alternative such as mussel oil holds great attraction. An increasing number of doctors are becoming willing to try natural treatments for their patients, as they  learn more about the medicinal properties of the mussel oil. There appears to be no downside to the use of the oil of the New Zealand green-lipped mussel. The oil of the New Zealand green-lipped mussel is consumed by people in 26 countries  who seek a variety of health benefits. A reduction in the inflammation that is associated with arthritis is just one of a list of benefits. During years of use and research, not one adverse reaction to the pure extracted oil of the New Zealand green-lipped mussel has been recorded.  Some doctors are sceptical, because early attempts to use the mussel had varying degrees of success. This was because the fragility of the medicinal properties of the mussel oil was not understood and, as a result, early mussel products

varied considerably in effectiveness. To date, only one

manufacturer has managed to extract and package the oil in a form that maintains its medicinal properties. This product, Lyprinol, is the result of a patented extraction process stabilises the mussel material (to prevent oxidisation), then uses liquid carbon dioxide to extract the oil. The oil of the New Zealand green-lipped mussel contains a unique combination of omega-3 and omega-6 marine lipids, as well as other unique compounds, which make it 200 times more effective as an anti-inflammataory than the best of the fish oils. It is also important to note that the mussel oil does not inhibit blood clotting, which can be a problem with fish oils. Scientific interest in the green-lipped mussel was piqued when doctors noted that the coastal Maori tribes of New Zealand enjoyed a low rate of arthritis and general good health to an advanced age. These coastal Maori attributed their good health to the consumption daily of raw green-lipped mussels. At the Princess Alexandra Hospital, in Brisbane, Dr Michael Whitehouse PhD conducted in vivo arthritis studies of rats. Dr Whitehouse compared the effectiveness of Lyprinol with other anti-inflammatory and anti-arthritic compounds. He found that, when administered orally, Lyprinol had a 93% to 97% effectiveness as an anti-inflammatory prescription drug.None of the other marine lipids, or pharmaceuticals such as indomethacin, was able to achieve a result that matched the effectiveness of Lyprinol.The great effectiveness of the green-lipped mussel was an elusive prize for researchers, until 1992 when Dr W. Henry Betts, the principal scientist at the Rheumatology Research Laboratory at the Queen Elizabeth Hospital, in South Australia, with the collaboration of the Royal Melbourne Institute of Technology and the University of Queensland, discovered some very active compounds in the mussel extract. Dr Betts discovered that some of the substances in the extract were the most potent anti-inflammatory compounds in his laboratory. It took two years of work to identify the effective compounds and develop the patented process by which the pure lipid could be extracted from the mussel. Researchers found that this lipid extract contained unique fatty acids that reduced inflammation in the body. They also identified carotenoids and other anti-oxidants, which circulate through the body to scavenge free radicals and protect the body against oxidative damage. Some of the combinations of omega-6 and omega-3 lipids extracted from the mussel modulate the inflammation process. All these substances are crucial to our good health. They affect our immune system, circulatory system and joints. The lipid fractions of the green-lipped mussel are, per weight, the most powerful anti-inflammatory marine oil available. The secret lies in its unique constituents. The green-lipped mussel has properties that have not been found in any other marine source.

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